Personified as gods, drugs Oxycontin and Adderall are at the center of this powerful novel inspired by the opioid epidemic.

Teen siblings Isaac and Ivy orbit different worlds. Isaac wants to study engineering. Ivy, who has ADD, feels like she’s tried everything and still has trouble focusing. When an ankle injury threatens Isaac’s soccer scholarship, he turns to Roxy to cope with the pain, while Ivy looks to Addi to bring focus to her life. As they struggle with their addictions, the once-close siblings find themselves divided.

As Isaac and Ivy head down a path to destruction, the seductive Roxy and pragmatic Addi make a bet to see who can get their “plus-one” to the Party (an otherworldly rave suggestive of altered states) and all the way to the VIP lounge — where they cannot escape.